Sildenafil blockiert die Phosphodiesterase-5 und steigert dadurch die intrazellulären cGMP-Konzentrationen. Die Wirkung setzt innerhalb von 30 bis 60 Minuten ein. Seine Halbwertszeit von vier Stunden macht den Wirkstoff zu einem Präparat mit kurzer Wirkdauer. Der Abbau erfolgt über CYP3A4 und CYP2C9, und die Elimination ist überwiegend biliär. Nebenwirkungen wie Kopfschmerzen und Hautrötungen sind vasodilatationsbedingt. Der Begriff viagra kaufen taucht häufig im Zusammenhang mit dem pharmakologischen Standard dieser Substanzklasse auf.
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- Pen Name - Miracle ina bottle!!!I have color treated hair that is naturally curly, thick but fine. I have tried tons of hydrating shampoo's and conditioner's from many many brands over my 40+ years. I have to tell you I was skeptical, but I found it easy to use. Smelled wonderful, who doesn't love lavender, and my hair was silky smooth and I could run my fingers through my curls WHEN DRY, and the curls bounced back. For you who don't have curly hair that's a big deal. I will get this again.... I am a Wen convert!!!
- Martha R. Boland "MartiB" - Abreva works!Have used this before and found best price here (as it can be expensive). I always have a tube on hand to stop cold sores as they start....works as well as oral prescription acyclovir (sp?). Highly recommend - just keep on had always.